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2009 modules |
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General module |
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Events |
Run 25 |
Run 26 |
Run 27 |
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Epitopes
to be detected1)
(click on underlined markers for
description)
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CD15,
CD30,
CK7,
CK20,
CK-LMW,
GCDFP/MAMGLO* |
AMACR/PIN-cocktail*
CD31,
CD68,
CD117,
p16 |
ASMA,
CD10,
CDX2,
CEA,
PSA/Prostein* |
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* Choose ONE of the two markers
indicated
Abbreviations: AMACR: alpha-methylacyl-CoA racemase,
(P504S protein); ASMA: alpha-smooth muscle
antigen; CDX2: Caudal related homeobox-2; CEA: Carcinoembryonic
antigen; HCALD: H-Caldesmon; CK: Cytokeratin; CK-LMW:
Cytokeratin, low molecular weight (the Ab should detect at least one primary/constitutive CK of simple epithelia, i.e., CK8 or CK18);
GCDFP: Gross cystic disease fluid protein-15 (select this OR
Mammaglobin); MAMGLO: Mammaglobin (select this
OR GCDFP);
PIN: Prostate intraepithelial neoplasia - cocktail, e.g. CK5/p63/AMACR; PSA: Prostate specific
antigen. |
Breast cancer module |
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Events |
Run B7
/ pilot C1 |
Run B8
/ pilot C2 |
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Epitopes
to be detected1)
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ER,
HER-2*,
Ki67 |
ER,
HER-2*,
SMH/p63** |
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* B7/B8:
HER-2 IHC, C1/C2: HER-2 CISH/SISH; ** Choose ONE of the two markers
indicated
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Abbreviations: ER: Estrogen receptor; SMH:
Smooth muscle heavy chain myosin (e.g., clone SMMS1). |
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2008 modules |
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General module |
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Events |
Run 22 |
Run 23 |
Run 24 |
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Epitopes
to be detected
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CD3,
CD15,
CDX2,
CGA,
MSH2,
SYP |
CR,
Ep-CAM,
IgK,
IgM,
TTF-1 |
CD5,
CD23,
CK-Pan,
MLA,
OCT3/4,
PLAP |
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Abbreviations: CDX2: Caudal related homeobox-2; CK-Pan: Pan- or broad spectrum cytokeratin (the Ab should detect at
least one primary/constitutive CK of simple epithelia, i.e., CK8 or
CK18, and one primary/constitutive CK of squamous epithelia,
i.e., CK5 or CK14); CGA: Chromogranin A; CR: Calretinin; Ep-CAM:
Epithelial cell-cell adhesion molecule (e.g., Ber-EP4 or MOC31);
IgK: Immunoglobulin kappa; IgM: Immunoglobulin M; MLA: Melan A;
MSH2: Mut-S homologue; 2OCT3/4: Octamer transcription factor 3/4;
PLAP: Placental alkaline phosphatase; SYP: Synaptophysin; TTF-1: Thyroid
transcription factor-1. |
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Breast module |
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Events |
Run B5 |
Run B6 |
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Epitopes
to be detected
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ECAD,
ER,
HER-21) |
CK-HMW,
HER-21),
PR |
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Abbreviations: CK-HMW: Cytokeratin
high
molecular weight
(the Ab should detect at least one primary/constitutive
CK of of squamous epithelia,
i.e., CK5 or CK14); ECAD: E-cadherin; ER: Estrogen receptor; PR: Progesterone receptor |
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2007 modules |
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General module |
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Events |
Run 19 |
Run 20 |
Run 21 |
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Epitopes
to be detected1)
(click for updated monographs)
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CD23,
CR,
CyD1,
Ki67,
Podop,
TTF1, |
CK-LMW,
CK-Pan,
MLA,
MSA,
p53, S100 |
ASMA,
CD20,
CD79a,
CD117,
CD138,
DES |
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Abbreviations: ASMA: alpha-smooth muscle
antigen; CK-LMW:
Cytokeratin, low molecular weight (the Ab should detect at least one primary/constitutive CK of simple epithelia, i.e., CK8 or CK18);
CK-Pan: Pan- or broad spectrum cytokeratin (the Ab should detect at
least one primary/constitutive CK of simple epithelia, i.e., CK8 or
CK18, and one primary/constitutive CK of squamous epithelia,
i.e., CK5 or CK14); CR: Calretinin;
CyD1: cyclin D1; DES: desmin; MLA: Melan A; MSA: melanosoma specific
antigen (HMB-45); Podop: podoplanin = D2-40; TTF1: thyroid
transcription factor-1. |
Breast module |
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Events |
Run B3 |
Run B4 |
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Epitopes
to be detected1)
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ER,
HER-21) |
HER-21),
PR |
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1) If a laboratory is unable to stain for HER-2, it can be
replaced by PR in Run B3 and ER in Run B4. Use the field "Other
epitope" in the protocol form. |
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Abbreviations: ER: Estrogen receptor, PR
Progesterone receptor |
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2006 modules
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General module |
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Events |
Run 16 |
Run 17 |
Run 18 |
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Epitopes to be detected1)
(click for updated monographs)
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AMACR,
CD10,
CK-LMW,
CK-HMW,
MLA,
p63 |
ALK,
bcl-6,
CD5,
CR,
CyD1,
Ep-CAM |
CGA,
IgK,
IgM,
NFP,
Syp,
TdT |
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Abbreviations: ALK: Anaplastic lymphoma kinase,
AMACR: alpha-methylacyl-CoA racemase, (P504S protein), CGA:
chromogranin A, CK-HMW: Cytokeratin, high molecular weight (the Ab
should detect at least one primary/constitutive CK of
complex/stratified epithelia, ie., CK5 or CK14), CK-LMW: Cytokeratin,
low molecular weight (the Ab should detect at least one
primary/constitutive CK of simple epithelia, i.e., CK8 or CK18), CR:
Calretinin, CyD1: Cyclin D1, Ep-CAM: Epithelial cellular adhesion
molecule (Abs., e.g., Ber-EP4 or MOC-31); IgK: Immunoglobulin Kappa;
IgM: Immunoglobulin M; NFP: Neurofilament protein, Syp: Synaptophysin,
TdT: Terminal deoxynucleotidyl transferase. |
Breast module |
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Events |
Run B1 |
Run B2 |
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Epitopes to be detected1)
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HER-21),
ER |
HER-21),
PgR |
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1) If a laboratory is unable to stain for HER-2, it can be
replaced by PgR in Run B1 and ER in Run B2. Use the field "Other
epitope" in the protocol form. |
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Abbreviations: ER: Estrogen receptor, PgR
Progesterone receptor |
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| MV/AS |
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Last
update
17-11-2009 |
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