Fig. 1a. HMB-45 staining of malignant melanoma. The epidermal tumours cells are intensely stained while the staining reaction is progressively lost as the tumours infiltrates dermis.

Fig. 1b. HMB-45 staining of malignant melanoma. A rather sparse dot-like staining is seen.

Fig. 1c. HMB-45 staining of a fine needle aspiration biopsy with malignant melanoma.

Fig. 1d. HMB-45 staining of an epitheloid PEComa infiltrating liver.