Mammaglobin

Characteristics

Mammaglobin, 10 kDa, is a cytoplasmic protein, a mammary-specific member of the uteroglobin family. It is related to a family of epithelial secretory proteins that includes prostatein and Clara cell protein.

Neoplasms

Mammaglobin occurs in about 80% of breast carcinomas. The extend is generally larger than that of GCDFP-15. Up to 15% of nonbreast carcinomas (such as stomach, lung, colon, hepatobiliary, thyroid, ovarian, and urothelial carcinomas) have been reported positive, usually only focally.

Application

Mammaglobin is a sensitive and fairly specific marker for breast carcinoma. The panel should also include Gross cystic disease fluid protein-15 and Estrogen receptor alpha.

Visualization

mAb clones 304-1A5 and 31A5 have been shown to give good results. HIER is mandatory, an alkaline buffer should be preferred.
Control: Skin - the eccrine sweat glands shall show an as strong as positive cytoplasmic reaction, while all other cells shall be negative.

Assessments

Run 25 2009