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AE1/AE3 versus KL1 stainings

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AE1AE3 immunoreaction in normal epidermis. All squamous epithelial cells are stained. Basal cells are strongly stained due to a high content of CK5 and CK14 and the high affinity of AE1AE3 to these CK subtypes.

KL1 immunoreaction in normal epidermis. Intermediate and superficial epithelial cells are intensively stained. Basal cells are unstained due to KL1's lacking affinity to CK5 and CK14.

AE1AE3 immunoreaction in a low differentiated squamous cell carcinoma. Almost all carcinoma cells cells are stained mainly due the content of CK5 and CK14. KL1 immunoreaction in a low differentiated squamous cell carcinoma (same field as the left picture). Only a few carcinoma cells are stained, due to the lacking affinity of KL1 to CK5 and CK14 expressed by the carcinoma cells. The weak positivity in the carcinoma cells is probably caused by other concomitant CK subtypes.  
MV/SN/AS

Last update 11-01-2004